ECVAM has set up several databases on alternative methods. The main database is DB-ALM (“dataset on alternative methods to animal experimentation”): click here
This database focuses mainly on methods submitted to EURL ECVAM for validation, and those identified in literature reviews between 2000 and 2019. All method and protocol abstracts are searchable via an intuitive web interface, and can be downloaded. Search criteria include thematic areas, biological parameters, experimental systems. There are 369 entries in 2021.
As a validation authority, ECVAM also makes available the TSAR database (“Tracking system for alternative methods towards regulatory aceptance”): click here
This database indicates the stages reached by methods in the regulatory acceptance process, as well as a summary description. Where available, TSAR also includes relevant records and documents associated with the method at the various stages of the process: submission, validation, peer review, recommendations and regulatory acceptance, including in international standards.
In addition, ECVAM has built up a knowledge base on non-animal models in a range of conditions to review existing methods and models in research activities.
- Neurodegenerative diseases
- Breast cancer
- Respiratory diseases
- Immuno-oncology
- Autoimmunity
- Cardiovascular diseases
- Immunogenicity of innovative products
To download them : click here
Proanima has set up a rich interface on New Methodological Approaches (NAMs), which is continually updated: NAMs Interface. This platform lists start-ups, biotech companies, laboratories, institutes and resources offering alternatives to animals for research, drug development, toxicology and education.
It also features a calendar of events relating to NAMs.
The FC3R, the French national 3R center, has also set up a directory of skills in alternative methods in France: click here
NORECOPA, the Norwegian center for the 3Rs, has developed a number of freely accessible databases, in particular the NORINA database, which provides information on over 3,500 alternative methods, audiovisual aids and products for use in education and training: click here
The Center for Alternatives to Animal Testing (CAAT), part of the Johns Hopkins Center in the USA, has a branch in Europe, at the University of Konstanz in Germany (click here).
This site provides information and news on alternative methods, organizes conferences, and hosts the ALTEX magazine: “Alternatives to Animal Experimentation”: click here
Other databases emanate from associative initiatives, such as the NAT (non-animal technologies) database, developed by the Association of German Doctors Against Animal Experimentation; it already includes over 500 entries, in oncology, toxicology, neurology, etc. The various models available are integrated: bioprinting, organs-on-a-chip, organoids, simulators, in silico methods… : click here
RE-Place, an online platform for New Approach Methodologies (NAMs) developed by Belgian researchers, already lists over 200 methods: click here
